Endocrine Abstracts

Introduction: Neuroglucopenic hypoglycaemia might be an underestimated threat of bariatric surgery, as Roux-en-Y gastric bypass (RYBG) or gastric sleeve. We aimed to evaluate glucose variability after bariatric surgery by continuous glucose monitoring (CGM) in a real-life setting.Methods: CGM was used in twelve patients with clinical suspicion of hypoglycaemia after undergoing bariatric surgery (RYBG or sleeve), during seven days. CGM was through using i...

Introduction: Craniopharyngiomas are rare epithelial tumors of the sellar and parasellar region, with high survival rates but with frequent tumor recurrence or persistence.Methods: Information collection from clinical records and review of the epidemiology, diagnosis, treatment and follow-up of patients with diagnosis of craniopharyngioma followed in an Endocrinology Department between 1980 and 2015. Statistical analysis using SPSS v. 22.0.<p class="...

Background: Optimal management of type 1 diabetes requires full understanding of the relationships between the triad: HbA1c, fasting plasma glucose, and glucose variability (GV). As GV may contribute to HbA1c we assessed the influence of GV in HbA1c levels.Research design and methods: We retrospectively analysed 9393 h of continuous glucose monitorings (CGMs) from 61 patients with type 1 diabetes. Periods of 24 h with missing values were excluded. We cal...

Introduction: Cushing’s disease (CD) is characterized by increased secretion of ACTH often as a result of a pituitary adenoma. The surgical success rates after transsphenoidal pituitary surgery (TSS) range from 53 to 96% in different centres. Postoperative cortisol levels have been proposed as the standard criteria for prediction of surgical remission however, this variable is subject of a variety of interferences.Objectives: Evaluate the potential ...

Introduction: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by proliferation/accumulation of cells phenotypically similar to skin Langerhans cells. Clinical presentation and aggressiveness are very heterogeneous, from benign to disseminated forms that cause significant morbi-mortality, particularly endocrine failures.Case 1: A 15-year-old Caucasian woman presented with a 14-month history of headaches, secondary amenorrhea. She repo...

Introduction: Medullary thyroid carcinoma (MTC) occurs in a hereditary pattern in 25% of cases. Virtually all patients with multiple endocrine neoplasia 2A (MEN2A) develop MTC. MTC aggressiveness and natural history varies according to the RET mutation. Prophylactic thyroidectomy may cure and/or prevent metastatic disease in most cases.Case report: A 27-year-old man with past history of colostomy at 5 months of age for Hirschsprung disease and t...

Introduction: Individuals with Turner syndrome (TS) are prone to develop autoimmune conditions. The most frequently found are Hashimoto’s thyroiditis, type 1 diabetes, coeliac disease, and inflammatory bowel disease. In patients with TS, Addison’s disease isolated or combined with other autoimmune disease as type 2 polyglandular autoimmune syndrome, is a rare finding.Case report: We report a case of a 41-year-old female patient, with severe ast...

Introduction: Factitious hypoglycemia results from surreptitious administration of insulin or insulin secretagogues. It can involve non-diabetic individuals with knowledge of hypoglycemiant drugs, or diabetics manipulating the doses.Clinical case: A 42-year-old women, type 1 diabetic since the age of 14, on intensive insulin therapy (A1C: 8.5%), was hospitalized for study of recurrent severe hypoglycemia in the last 2 months, despite successive insulin d...

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for Graves’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....

Introduction: Methimazole is the thionamide compound most used in the treatment of hyperthyroidism due to its efficacy, commodity and security. Severe side effects are rare, although potentially fatal: agranulocytosis in 0.1–0.5% and toxic hepatitis in 0.1%Aims: To characterize the patients admitted in the endocrinology ward for the last 10 years for severe complications of methimazole therapy.Material and Methods: Retrospecti...